A 2000 study that looked at the treatment outcomes of spinal manipulation and ischemic compression in fibromyalgia patients revealed a significant decrease in pain (77.2%), improvements in sleep quality (63.5%) and lessening of fatigue (74.8%) for one month after treatment. 

• Hains G, Hains F. Combined ischemic compression and spinal manipulation in the treatment of fibromyalgia: a preliminary estimate of dose and efficacy. Journal of Manipulative and Physiological Therapeutics 23(4):225-230, 2000.